Studies on Carbohydrates Derivatives. I

Studies on glycoprotein-derived carbohydrates.

43 Res. 49,3314-3320 Rubin, J. S., Chan, A. M. L., Bottaro, D. P., Burgess, W. H., Taylor, W. G., Cech, A. C., Hirschfield, D. W., Wong, J., Miki, T., Finch, P. W. and Aaronson, S. A. (1991) Proc. Natl. Acad. Sci. U.S.A. 88,415-419 Rosen, E. M., Goldberg, I. D., Kacinski, B. M., Buckholz, T. and Vinter, D. W. (1989) In Vitro 25, 163-173 Zarnegar, R., De Frances, M. C., Oliver, I,. and Michalopo...

Computational studies on carbohydrates: I. Density functional ab initio geometry optimization on maltose conformations

Ab initio geometry optimization was carried out on 10 selected conformations of maltose and two 2-methoxytetrahydropyran conformations using the density functional denoted B3LYP combined with two basis sets. The 6-31G∗ and 6-311++G∗∗ basis sets make up the B3LYP/6-31G∗ and B3LYP/6-311++G∗∗ procedures. Internal coordinates were fully relaxed, and structures were gradient optimized at both levels...

Studies on nicotinamide derivatives.

Synthesis of Furan Derivatives Condensed with Carbohydrates

Eight new furan derivatives have been prepared and characterized. These compounds were obtained by condensation of aminosugar and aminocyclitol intermediates with furan derivatives.

Lipophilicity Studies on Thiosemicarbazide Derivatives.

The lipophilicity of two series of thiosemicarbazide derivatives was assessed by the RP-HPLC method with the RP-18 chromatographic column and the methanol-water mixture as the mobile phase. Distribution coefficients logPHPLC were compared to calculated values generated by commonly used AClogP software and quantum chemical calculations. The reliability of the predictions was evaluated using the ...